There has been a concern that there is a significant muscle loss when you are on GLP-1s. A new paper published in JAMA this week plays down that concern. The paper states that: 1. It is unlikely that the decline in SMM (muscle mass) that occurs with even large amounts of weight loss impairs physical [...]

Two new large observational studies show GLP-1 drugs are associated with reduced dementia in people with diabetes. The Swedish study included 88,381 participants. The researchers found that people taking GLP-1 agonists had a 31% lower risk of developing dementia compared to those taking sulfonylureas, and a 23% lower risk compared to those taking DPP-4 inhibitors. [...]

Daily multivitamins may not promote longevity This should not really be a surprise for anyone, but…. 1. A new study from the National Institutes of Health suggests that daily multivitamin use may not improve the life span of generally healthy adults. 2. New research analyzing data from over two decades and nearly 400,000 participants in [...]

Consider the following: 1. 0% of all heart attacks have no warning or precedent. No pain, no shortness of breath 2. Most individuals have no symptoms from a growing cancer until it has reached stage-3 or stage-4, by which time the chances of a full remission are vastly reduced. It’s extreme that most people know [...]

The ultimate downside risk Something seems to happen after the age of 45..... It is from in the age bracket 45-55 that all major disease risk goes from close to zero to a much higher number. Do your Executive Health check-up from the age of 45.

Harvard Neurologist Says To Treat Dementia Like Heart Disease Rudolph E. Tanzi, who has a doctorate in neurology and is a professor of neurology at Harvard Medical School and the director of its Genetics and Aging Research Unit, said that to stop dementia and Alzheimer’s, doctors must treat it the way they currently treat heart [...]

Here are 10 great quotes / insights from Peter Attia’s latest podcast episode on longevity. 1. If your definition of longevity is “I want to live to be 200,” I wouldn’t be able to help you. The way I think about it is longevity means how do we live longer? I think that means years [...]

It’s still very early in the era of A.I. in medicine, especially with LLMs. Progress in medical A.I. won’t occur in a straight line. Doctor Eric Topol does a very good job summarizing some of the latest findings. One big step forward with a 16.000 patient study that showed a statistically significant 17% reduction of [...]