Longevity influencers and popular culture often highlight Nicotinamide Adenine Dinucleotide (NAD+) as the latest “miracle molecule” to slow ageing and support cellular energy production.
According to the New York Times article “Longevity Seekers Are Taking N.A.D.+ Supplements. Do They Work?” (October 2025), interest is rising sharply — but the evidence for real clinical benefit is surprisingly weak.
“The literature is very scarce… the science is almost nonexistent.”
— Prof Trebak, Novo Nordisk (via NYT)
What does the research say?
– In preclinical experiments (mice and cells), NAD+ precursors have shown promising effects on mitochondria, metabolism and inflammation.
– The human studies have been “very small and the results have been modest.” Even though some supplements raise NAD+ levels in the blood, they have not consistently improved key clinical measures such as insulin sensitivity, muscle strength or biological age.
Despite the hype around NAD+, there is still no evidence that supplements extend life or slow ageing in humans.
In the mouse lab it may look promising – but in real life, the research is still at the starting line.
Conclusion:
NAD+ should definitely not be at the core of a longevity strategy.
At Executive Health, we of course prioritise the proven cornerstones: exercise, nutrition, sleep and regular screening.
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